反应详情

A mixture of 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphtalene-2-yl)-ethoxy)-benzaldehyde (350 mg; 1.0 mmol), 2,4-thiazolidinedione (129 mg; 1.1 mmol), piperidine (1 drop) and acetic acid (1 drop) in toluene (10 ml) was refluxed for 3 hours using a water separator. Upon cooling to room temperature the product precipitated. Filtration gave the title compound in 325 mg (72%) yield.

1. temperaturewas refluxed for 3 hours
2. customprecipitated
3. filtrationFiltration