反应详情

A mixture of ethyl 5-(2-thienyl)pentanoate (15.40 g), sodium hydroxide (NaOH) (2.90 g), water (H2O) (18 ml), and tetrahydrofuran (THF) (100 ml) was stirred at reflux for 2.5 hours. The reaction mixture was poured into a mixture of water and diethyl ether (Et2O). The aqueous layer was separated, and acidified with 6 N hydrochloric acid (HCl), and extracted with ethyl acetate (AcOEt). The organic layer was washed with water and brine, and dried over magnesium sulfate (MgSO4), and evaporated to give 5-(2-thienyl)pentanoic acid (12.07 g) as an oil.

1. temperatureat reflux for 2.5 hours
2. customThe aqueous layer was separated
3. extractionextracted with ethyl acetate (AcOEt)
4. washThe organic layer was washed with water and brine
5. dry with materialdried over magnesium sulfate (MgSO4)
6. customevaporated