HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Methyl (1RS, 3SR)-trans-1,3-dihydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (1RS, 3SR)-trans-1,3-dihydroxymethyl-1,2,3,4-tetrahydro-beta-carboline | HCID 86741010 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl (1RS, 3SR)-trans-1,3-dihydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate | HCID 86741009 | — |
Reaction Steps
In the same manner as described in Example 13 by using (1RS, 3SR)-trans-1,3-dihydroxymethyl-1,2,3,4-tetrahydro-β-carboline (0.65 g), triethylamine (0.79 ml), CS2 (0.34 ml), methyl iodide (0.35 ml) and dimethylsulfoxide (6 ml), there is prepared the title compound (350 mg, 39%) as colorless needles, m.p. 179°-180° C. (recrystallized from water-ethanol). NMR (CDCl3 -DMSO-d6, δ): 2.66 (s, 3H, CSSCH3), Mass m/e: 304 (M+ --H2O), 274 (M+ --CH3SH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04612317 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-b894784734034d4293e519a666e69275 |
| Source note | uspto-grants-1986_09 |