Pyridine-4-amidine hydrochloride → 4-Phenyl-2-pyridin-4-ylpyrimidine-5-carboxylic acid

HRID 650624Notes

Reaction equation

HRID 650624 reaction equation
C([O:3][C:4](=[O:18])[C:5]([C:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[CH:6]N(C)C)C.Cl.[C:20]([NH2:28])(=[NH:27])[C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1>>[C:11]1([C:10]2[C:5]([C:4]([OH:18])=[O:3])=[CH:6][N:28]=[C:20]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)[N:27]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 2776844Pyridine-4-amidine hydrochlorideHCID 54499154Ethyl-2-benzoyl-3-dimethylaminopropenoate

Product 1

HCID 217124194-Phenyl-2-pyridin-4-ylpyrimidine-5-carboxylic acid

Procedure

In an analogous manner to that described in example 3b) starting from 2-benzoyl-3-dimethylamino-acrylic acid ethyl ester and isonicotinamidine hydrochloride, followed by saponification as described in example 3c) there was obtained 4-phenyl-2-pyridin-4-yl-pyrimidine-5-carboxylic acid.

Sources & evidence

ORD record
ord-9dfd58e018984f5aaf74b26b101d5d73
Source dataset
uspto-grants-2001_08
Patent number
US06274588B1

Reaction notes

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