HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Methyl (1RS, 3RS)-cis-3-hydroxymethyl-1-phenyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (1RS, 3RS)-cis-3-hydroxymethyl-1-phenyl-1,2,3,4-tetrahydro-beta-carboline | HCID 86741014 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl (1RS, 3RS)-cis-3-hydroxymethyl-1-phenyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate | HCID 86741013 | 78.1% |
Reaction Steps
In the same manner as described in Example 13 by using (1RS, 3RS)-cis-3-hydroxymethyl-1-phenyl-1,2,3,4-tetrahydro-β-carboline (300 mg) [J.A.C.S., 102, 6976 (1980)], triethylamine (220 mg), CS2 (160 mg), methyl iodide (306 mg) and dimethylsulfoxide (6 ml), there is prepared the title compound (310 mg, 78%) as white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04612317 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-f8c6ec9088e142c8b9185f979e4f3ff4 |
| Source note | uspto-grants-1986_09 |