反应详情

To a mixture of 3-tert-Butoxycarbonylamino-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid (200 mg, 0.51 mmol), [2-(4-Amino-phenyl)-ethyl]-carbamic acid tert-butyl ester (130 mg, 0.55 mmol), HOBT (82 mg, 0.612 mmol) in DMF (25 mL), was added 1-(3-dimethylamino) propyl)-3-ethylcarbodiimide hydrochloride (118 mg, 0.612 mmol). The reaction was stirred overnight at room temperature. Insoluble particles were removed by filtration and the solvent was evaporated. Purification of the residue on silica gel (1:4 hexane:EtOAc) gave 144 mg (42%) of pure [2-[4-(2-tert-Butoxycarbonylamino-ethyl)-phenylcarbamoyl]-2-(2,4,6-trimethyl-benzenesulfonylamino)-ethyl]-carbamic acid benzyl ester (Y-2).

1. customInsoluble particles were removed by filtration
2. customthe solvent was evaporated
3. customPurification of the residue on silica gel (1:4 hexane:EtOAc)