HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → 4-(N-Formylamino)benzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline | HCID 13375506 | — |
| Reactant | 4-(N-formylamino)benzyl chloride | HCID 20225704 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(N-Formylamino)benzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate | HCID 13392985 | 58% |
Reaction Steps
In the same manner as described in Example 29 by using (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (1.21 g), triethylamine (0.84 ml), CS2 (0.36 ml), 4-(N-formylamino)benzyl chloride (1.02 g) and dimethylsulfoxide (30 ml), there is prepared the title compound (1.43 g, 58%) as pale yellow powder, [α]D20 +120.2° (c=1.0, dimethylformamide); NMR (DMSO-d6, δ): 4.54 (s, 2H, ##STR12## Mass m/e: 244 (M+ -- ##STR13##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04612317 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-e17f56a49aa349adbb9e58a2e2bdf171 |
| Source note | uspto-grants-1986_09 |