HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → 4-Methoxybenzyl (3RS)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | {1H,2H,3H,4H,9H-pyrido[3,4-b]indol-3-yl}methanol | HCID 13375505 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-Methoxybenzyl (3RS)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline-2-carbodithioate | HCID 13859047 | 71% |
Reaction Steps
In the same manner as described in Example 29 by using (3RS)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (1.01 g), triethylamine (0.7 ml), CS2 (0.3 ml), 4-methoxybenzyl chloride (1.0 g) and dimethylsulfoxide (5 ml), there is prepared the title compound (1.41 g, 71%) as white powder, NMR (CDCl3 +DMSO-d6, δ): 4.52 (s, 2H, ##STR16## Mass m/e: 398 (M+), 244 (M+ -- ##STR17##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04612317 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-eb7cdabd6ecb42389b6cd87ae29973cd |
| Source note | uspto-grants-1986_09 |