反应详情

温度

0 °C

To a solution of ethyl (1R)2R)-1-hydroxy-1-(4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)-indene-2-carboxylate (0.80 g, 1.9 mmol) in CH2Cl2 (10 ml) at 0° C. under an argon atmosphere was added triethylsilane (0.28 a, 2.4 mmol), followed by boron tritluoride etherate (1 ml, 8.1 mmol). The resulting solution was stirred at 0° C. for 10 min, and was then partitioned between EtOAc and 3M HCl. The organic extract was washed with saturated aqueous NaCl and dried (MgSO4). The solvent was removed in vacun, and the residue was filtered through a pad of silica gel, eluting with CH2Cl2. The title compound (mixture of Δ1 and Δ2 double bond isomers) was obtained as a glassy, yellow solid (0.72 g, 94%).

1. customwas then partitioned between EtOAc and 3M HCl
2. extractionThe organic extract
3. washwas washed with saturated aqueous NaCl
4. dry with materialdried (MgSO4)
5. customThe solvent was removed in vacun
6. filtrationthe residue was filtered through a pad of silica gel
7. washeluting with CH2Cl2