反应详情

温度

65 °C

A mixture of 5 g of 6-bromo-2-naphthol, 50 ml of dimethyl sulfoxide, 3.9 ml of 6-bromoheptane, 7.1 g of potassium iodide and 7.1 g of milled potassium carbonate activated at 80° C. in high vacuum is heated to 65° C. for 16 hours. It is then cooled and is partitioned between ethyl acetate and water and the organic phase is washed several times with water, dried over magnesium sulfate, filtered and evaporated down. Chromatography of the residue over 200 g of silica gel using toluene and subsequent crystallization from toluene/hexane (8:1) give 6-bromo-2-heptyloxynaphthalene.

1. customactivated at 80° C. in high vacuum
2. temperatureIt is then cooled
3. customis partitioned between ethyl acetate and water
4. washthe organic phase is washed several times with water
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated down
8. customtoluene and subsequent crystallization from toluene/hexane (8:1)