反应详情

A mixture of 0.39 g of alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile, 1 ml of 37% formalin, and 1 ml of 90% formic acid was refluxed for 1 hour. After cooling, to the mixture were added water and potassium carbonate to make it alkaline. The solution was extracted with chloroform. The extract was washed with water, dried, and evaporated to give 0.23 g of desired compound as a yellow oil.

1. temperaturewas refluxed for 1 hour
2. temperatureAfter cooling, to the mixture
3. extractionThe solution was extracted with chloroform
4. washThe extract was washed with water
5. customdried
6. customevaporated