methyl 2-iodo-3-methoxybenzoate → methyl 2',6-dimethoxybiphenyl-2-carboxylate

HRID 650921Notes

Reaction equation

HRID 650921 reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[C:5]=1I.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1B(O)O>>[CH3:1][O:2][C:3]([C:4]1[C:5]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[O:15][CH3:14])=[C:6]([O:10][CH3:11])[CH:7]=[CH:8][CH:9]=1)=[O:13]

Participants

3

Reactant 2

HCID 299486methyl 2-iodo-3-methoxybenzoateHCID 27339582-Methoxyphenylboronic acid

Product 1

HCID 282428methyl 2',6-dimethoxybiphenyl-2-carboxylate

Procedure

Using the procedure outlined in Step A of Example 18, 201.7 mg (0.69 mmol) of methyl-2-iodo-3-methoxy-benzoate and 125.9 mg (0.82 mmol) of 2-methoxy-phenylboronic acid gave after 27 hours of reflux a quantitative yield of the title substance.

Workup

  1. customgave after 27 hours
  2. temperatureof reflux a quantitative yield of the title substance

Sources & evidence

ORD record
ord-b9779ce725614451a9787927c946bbc3
Source dataset
uspto-grants-2001_08
Patent number
US06277843B1

Reaction notes

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