反应详情

温度

80 °C

Copper(I) cyanide (12 mmol) is added to 10 mmol of 6-amino-3-bromo-2-methylpyridine dissolved in dimethylformamide. The mixture is refluxed for 10 hours, and then cooled to 80° C. and poured into a solution of sodium cyanide (40 mmol) in water. After stirring for 1 hour at room temperature, the mixture is extracted with ethyl acetate. The organic phase is washed, then dried and evaporated to yield the expected product in the form of an ochre solid.

1. temperatureThe mixture is refluxed for 10 hours
2. extractionthe mixture is extracted with ethyl acetate
3. washThe organic phase is washed
4. customdried
5. customevaporated