4-(4-Oxazol-2-ylphenyl)piperazine → 2-[3-(2-Aminoethyl)-1h-indol-5-yloxy]-1-[4-(4-oxazol-2-ylphenyl)piperazin-1-yl]ethanone fumarate

HRID 650930Notes

Reaction equation

HRID 650930 reaction equation
[O:1]1C=C[N:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17]CNCC2)=[CH:8]C=1.N[C@H:19]([C:22]([C:24]([O:26][C:27]([CH3:30])([CH3:29])C)=[O:25])=[O:23])[CH2:20][OH:21].[C:31]1([C:37]2[O:41][C:40]([C:42]3[CH:47]=[CH:46][C:45]([N:48]4[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]4)=[CH:44][CH:43]=3)=[N:39]N=2)C=CC=CC=1>>[C:24]([OH:26])(=[O:25])/[CH:22]=[CH:19]/[C:20]([OH:21])=[O:1].[NH2:3][CH2:2][CH2:6][C:11]1[C:10]2[C:9](=[CH:8][CH:30]=[C:27]([O:26][CH2:24][C:22]([N:51]3[CH2:50][CH2:49][N:48]([C:45]4[CH:44]=[CH:43][C:42]([C:40]5[O:41][CH:37]=[CH:31][N:39]=5)=[CH:47][CH:46]=4)[CH2:53][CH2:52]3)=[O:23])[CH:29]=2)[NH:12][CH:17]=1

Participants

4

Reactant 3

HCID 185048364-(4-Oxazol-2-ylphenyl)piperazineHCID 185048391-[4-(5-Phenyl-[1,3,4]oxadiazol-2-yl)phenyl]piperazineHCID 57270561SerBOC

Product 1

HCID 185048452-[3-(2-Aminoethyl)-1h-indol-5-yloxy]-1-[4-(4-oxazol-2-ylphenyl)piperazin-1-yl]ethanone fumarate

Procedure

Compound 6 is prepared from intermediate 6A (54 mg; 0.16 mmol) and SerBOC acid (53 mg; 0.16 mmol) according to the procedure described for the preparation of Example 1 from 1C.

Sources & evidence

ORD record
ord-a7978e6e43a84096942b10e4b385d0df
Source dataset
uspto-grants-2001_08
Patent number
US06277853B1

Reaction notes

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