HCID 13714726, compound → HCID 13714728, compound

HRID 65094Notes

Reaction equation

HRID 65094 reaction equation
[CH:1]([C:4]([C:24]1[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=1)([CH2:7][CH2:8][CH2:9][NH:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-])=O)[C:5]#[N:6])([CH3:3])[CH3:2]>CO.[Pt]=O>[CH:1]([C:4]([C:24]1[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=1)([CH2:7][CH2:8][CH2:9][NH:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH2:21])[C:5]#[N:6])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 13714726HCID 13714726, compound

Product 1

HCID 13714728HCID 13714728, compoundYield 97.2%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

4.78 g of alpha-isopropyl-alpha-[3-[N-[3-(2-nitrophenoxy)propyl]amino]propyl]-3,4,5-trimethoxyphenyl-acetonitrile was hydrogenated in 100 ml of methanol over 50 mg of platinum oxide at atmospheric pressure and room temperature. The catalyst was filtered off and filtrate was evaporated to give 4.36 g of desired compound as a pale yellow oil.

Workup

  1. filtrationThe catalyst was filtered off
  2. customfiltrate was evaporated

Sources & evidence

ORD record
ord-0def383bcd52460d8c89ff77202dcd60
Source dataset
uspto-grants-1986_09
Patent number
US04612329

Reaction notes

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