Methyl iodide → 7-Amino-2-methyl-3,4-dihydroisoquinolinium iodide

HRID 650948Notes

Reaction equation

HRID 650948 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[I:12][CH3:13]>CC(C)=O>[I-:12].[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N+:8]([CH3:13])=[CH:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 114236673,4-Dihydroisoquinolin-7-amine

Product 1

HCID 111089627-Amino-2-methyl-3,4-dihydroisoquinolinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

7-amino-3,4-dihydroisoquinoline (0.40 g, 2.74 mmol) in acetone (125 ml) was treated with iodomethane (0.50 ml, 8.03 mmol) and left stirring at room temperature for 18 h. The resultant yellow precipitate was collected by filtration and dried in vacuo at ambient temperature (0.73 g, 92%). m/z (API)=161 (M)+

Workup

  1. waitleft
  2. filtrationThe resultant yellow precipitate was collected by filtration
  3. customdried in vacuo at ambient temperature (0.73 g, 92%)

Sources & evidence

ORD record
ord-a31009c6874141d691607b362acda856
Source dataset
uspto-grants-2001_08
Patent number
US06277861B1

Reaction notes

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