HCID 13714730, compound → HCID 13714732, compound

HRID 65097Notes

Reaction equation

HRID 65097 reaction equation
[CH:1]([C:4]([C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([O:33][CH3:34])=[C:27]([O:35][CH3:36])[CH:26]=1)([CH2:7][CH2:8][CH2:9][N:10]([CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+:22]([O-])=O)[CH3:11])[C:5]#[N:6])([CH3:3])[CH3:2]>CO.[Pt]=O>[CH:1]([C:4]([C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([O:33][CH3:34])=[C:27]([O:35][CH3:36])[CH:26]=1)([CH2:7][CH2:8][CH2:9][N:10]([CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[NH2:22])[CH3:11])[C:5]#[N:6])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 13714730HCID 13714730, compound

Product 1

HCID 13714732HCID 13714732, compoundYield 105.2%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

0.92 g of alpha-isopropyl-alpha-[3-[N-[3-(2-nitrophenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile was hydrogenated in 20 ml of methanol over 10 mg of platinum oxide at atmospheric pressure and room temperature. The catalyst was filtered off and filtrate was evaporated to give 0.91 g of the desired compound as a yellow oil. The oxalate of this compound was obtained in the usual manner.

Workup

  1. filtrationThe catalyst was filtered off
  2. customfiltrate was evaporated

Sources & evidence

ORD record
ord-2f0e8264333b4780b3d6f70d45b41568
Source dataset
uspto-grants-1986_09
Patent number
US04612329

Reaction notes

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