反应详情

To a solution of ethyl 4-acetylbenzoate (5.12 g, 26.6 mmol) in ether (50 ml) containing aluminium chloride (0.025 g, 0.19 mmol) is added bromine (1.31 ml, 26.6 mmol) and the reaction mixture is stirred for 2 h. The reaction mixture is poured into saturated NaHCO3 solution and stirred for 30 min. and the layers are separated. The organic layer is washed with NaHCO3, H2O, dried over MgSO4, concentrated to half of its volume and refrigerated overnight. The resulting solid is filtered to yield ethyl 4-(2′-bromoacetyl)benzoate (5.89 g, 81.6%) as white crystals.

1. stirringstirred for 30 min.
2. customthe layers are separated
3. washThe organic layer is washed with NaHCO3, H2O
4. dry with materialdried over MgSO4
5. concentrationconcentrated to half of its volume and refrigerated overnight
6. filtrationThe resulting solid is filtered