4-Toluenesulfonyl chloride → N-(2-Benzoyl-6-Chloro-1H-Indol-3-Yl)4-Methylbenzenesulfonamide

HRID 651024Notes

Reaction equation

HRID 651024 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4](C(OCC)=O)[C:3]=1[C:17](=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[C:25]1([CH3:35])[CH:30]=[CH:29][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:27][CH:26]=1>>[C:17]([C:3]1[NH:4][C:5]2[C:10]([C:2]=1[NH:1][S:31]([C:28]1[CH:29]=[CH:30][C:25]([CH3:35])=[CH:26][CH:27]=1)(=[O:33])=[O:32])=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=2)(=[O:24])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 183678333-Amino-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole

Product 1

HCID 9932168N-(2-Benzoyl-6-Chloro-1H-Indol-3-Yl)4-Methylbenzenesulfonamide

Procedure

The title compound was prepared according to the procedure described in Example 33 from ethyl 3-amino-2-benzoyl-6-chloro-1H-indole-1-carboxylate (Example 1, step 2) and p-toluenesulfonyl chloride.

Sources & evidence

ORD record
ord-42af586597c74fc3b8878bc11e69d17c
Source dataset
uspto-grants-2001_08
Patent number
US06277878B1

Reaction notes

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