Dimethylamine, hydrochloride → HCID 54328108, compound

HRID 651099Notes

Reaction equation

HRID 651099 reaction equation
Cl.[CH3:2][NH:3][CH3:4].[Cl:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]([C:15]([NH:17][CH:18]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:19](O)=[O:20])=[O:16])=[CH:9]2>>[CH3:2][N:3]([CH3:4])[C:19]([CH:18]([NH:17][C:15]([C:10]1[NH:11][C:12]2[C:8]([CH:9]=1)=[CH:7][C:6]([Cl:5])=[CH:14][CH:13]=2)=[O:16])[CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:20]

Participants

3

Reactant 2

HCID 10473Dimethylamine, hydrochlorideHCID 155210162-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionic acid

Product 1

HCID 54328108HCID 54328108, compound

Procedure

Dimethylamine hydrochloride (0.96 mmol) and 2-[(5-chloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionic acid (0.90 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, 60 hour reaction time, washed first with acid, then base), and the resulting solid triturated with ether: Yield 320 mg, 99%; HPLC (60/40) 5.87 minutes (100%);

Workup

  1. custom0-25° C. reaction temperature, 60 hour reaction time
  2. washwashed first with acid
  3. custombase), and the resulting solid triturated with ether
  4. customHPLC (60/40) 5.87 minutes (100%)

Sources & evidence

ORD record
ord-3d8e261e0bdc4cc1bdbed7dfcc8628c0
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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