Thiazolidine → HCID 53784664, compound

HRID 651113Notes

Reaction equation

HRID 651113 reaction equation
[S:1]1[CH2:5][CH2:4][NH:3][CH2:2]1.[C:6]([NH:13][CH2:14][C:15](O)=[O:16])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7]>>[C:9]([O:8][C:6](=[O:7])[NH:13][CH2:14][C:15](=[O:16])[N:3]1[CH2:4][CH2:5][S:1][CH2:2]1)([CH3:12])([CH3:10])[CH3:11]

Participants

3

Reactant 2

HCID 10444ThiazolidineHCID 78288N-(tert-butoxycarbonyl)glycine

Product 1

HCID 53784664HCID 53784664, compound

Procedure

Thiazolidine (85 mmol) and Boc-glycine (57 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, 60 hour reaction time) and the product used without purification. Yield 12.7 g, 90%.

Workup

  1. customthe product used without purification

Sources & evidence

ORD record
ord-3ee08179b7aa48bba004061ee247a032
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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