L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- → HCID 10497933, compound

HRID 651125Notes

Reaction equation

HRID 651125 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:8]([NH:15][C@H:16]([C:24](O)=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]>>[C:11]([O:10][C:8](=[O:9])[NH:15][C@@H:16]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:24]([N:5]1[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]1)=[O:25])([CH3:14])([CH3:12])[CH3:13]

Participants

3

Reactant 2

HCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-HCID 79341Piperidin-4-ol

Product 1

HCID 10497933HCID 10497933, compound

Procedure

4-Hydroxypiperidine (75 mmol) and Boc-L-phenylalanine (38 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, 144 hour reaction time) and the product used without further purification. Yield 12.2 g, 96%; HPLC (60/40) 3.45 minutes (97%).

Workup

  1. customthe product used without further purification
  2. customHPLC (60/40) 3.45 minutes (97%)

Sources & evidence

ORD record
ord-9e45c27fdaf44d4abc33bf6fc5e7d024
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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