HCID 468478, compound → HCID 69688732, compound

HRID 651127Notes

Reaction equation

HRID 651127 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9](=[O:16])[N:10]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11]1)(C)(C)C.[ClH:25].O1CCOCC1>>[ClH:25].[NH2:7][C@@H:8]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]([N:10]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11]1)=[O:16]

Participants

3

Reactant 2

HCID 468478HCID 468478, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 69688732HCID 69688732, compound

Conditions

Temperature
25 °C

Procedure

(S)-[1-Benzyl-2-oxo-2-(3-oxo-pyrrolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (552 mg, 1.7 mmol) was dissolved in 4M HCl-dioxane (6.2 mL) at 0° C. The mixture was stirred at 25° C. for 1 hour, concentrated and the residue triturated with ether to give alight brown solid. Yield, 482 mg, 108%.

Workup

  1. concentrationconcentrated
  2. customthe residue triturated with ether
  3. customto give alight brown solid
  4. customYield

Sources & evidence

ORD record
ord-63348ef3142a4c519944e519219e2e3d
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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