1,4-Dioxane hydrochloride → HCID 66548467, compound

HRID 651131Notes

Reaction equation

HRID 651131 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9](=[O:16])[N:10]1[CH2:15][CH2:14][S:13][CH2:12][CH2:11]1)(C)(C)C.[ClH:25].O1CCOCC1>>[ClH:25].[NH2:7][C@@H:8]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]([N:10]1[CH2:15][CH2:14][S:13][CH2:12][CH2:11]1)=[O:16]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 52530575HCID 52530575, compound

Product 1

HCID 66548467HCID 66548467, compound

Conditions

Temperature
25 °C

Procedure

(S)-(1-Benzyl-2-oxo-2-thiomorpholin-4-yl-ethyl)-carbamic acid tert-butyl ester (17.8 mmol) was dissolved in 4M HCl-dioxane (67 mL) at 0° C., the solution stirred at 25° C. for 1 hour, the reaction concentrated and the residue triturated with ether. Yield, 5.0 g, 98%; PBMS 251 (MH+, 100%).

Workup

  1. concentrationthe reaction concentrated
  2. customthe residue triturated with ether
  3. customYield

Sources & evidence

ORD record
ord-53f00d2017fb4ab084c5532420902580
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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