HCID 7201349, compound → HCID 13689667, compound

HRID 651153Notes

Reaction equation

HRID 651153 reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:16](=[O:19])[NH:17][CH3:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.[ClH:21].O1CCOCC1>>[ClH:21].[NH2:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]([NH:17][CH3:18])=[O:19]

Participants

3

Reactant 2

HCID 7201349HCID 7201349, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 13689667HCID 13689667, compound

Conditions

Temperature
25 °C

Procedure

(R)-(1-Methylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (722 mg, 2.6 mmol) was dissolved in 4M HCl-dioxane (10 mL) at 0° C. The mixture was stirred for 1 hour at 25° C., concentrated and the residue triturated with ether. Yield, 517 mg, 93%.

Workup

  1. concentrationconcentrated
  2. customthe residue triturated with ether
  3. customYield

Sources & evidence

ORD record
ord-e3880eb35d8f4dcca92489751a8cb03b
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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