HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 651155Generated: October 31, 2026
(1-Dimethylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester → (2S)-2-Amino-N,N-dimethyl-3-phenylpropanamide hydrochloride
https://huagongshe.com/reaction/651155
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (1-Dimethylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester | HCID 14541823 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | (2S)-2-Amino-N,N-dimethyl-3-phenylpropanamide hydrochloride | HCID 12653778 | — |
Reaction Steps
(1-Dimethylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (8.6 g, 29 mmol) was dissolved in 4 M HCl-dioxane (110 ml) at 0° C. and the mixture stirred at 25° C. for 1 hour. The mixture was concentrated and the solids triturated with ether. Yield, 6.2 g, 92%; PBMS 193 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06277877B1 |
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| Source dataset | uspto-grants-2001_08 |
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| ORD ID | ord-596a9f47d2a54c049817a93e35a8c7cc |
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| Source note | uspto-grants-2001_08 |
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