Hydrazine hydrate (1:1) → HCID 13519851, compound

HRID 65117Notes

Reaction equation

HRID 65117 reaction equation
[CH2:1]([S:8][C:9]1[N:14]=[C:13](Cl)[CH:12]=[C:11]([CH2:16][CH2:17][CH3:18])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:20][NH2:21]>C(O)C>[CH2:1]([S:8][C:9]1[N:14]=[C:13]([NH:20][NH2:21])[CH:12]=[C:11]([CH2:16][CH2:17][CH3:18])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13519850HCID 13519850, compound

Product 1

HCID 13519851HCID 13519851, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 40 g (0.014 mole) of 2-benzylthio-4-chloro-6-n-propylpyrimidine (from Part B) and 15 g (0.3 mole) of hydrazine hydrate in 300 ml of ethanol was heated at reflux for 2 hours, cooled and evaporated. Water was added to the residue. The white solid was collected by filtration and dried to provide 2-benzylthio-4-hydrazino-6-n-propylpyrimidine. The structural assignment was confirmed by infrared and nuclear magnetic resonance spectral analyses.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. temperaturecooled
  4. customevaporated
  5. additionWater was added to the residue
  6. filtrationThe white solid was collected by filtration
  7. customdried

Sources & evidence

ORD record
ord-d144ecdb09de4be7a01d8d916513c97a
Source dataset
uspto-grants-1986_09
Patent number
US04612375

Reaction notes

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