1,4-Dioxane hydrochloride → HCID 69687670, compound

HRID 651189Notes

Reaction equation

HRID 651189 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:9]([N:11]1[CH2:14][CH:13]([OH:15])[CH2:12]1)=[O:10])(C)(C)C.[ClH:24].O1CCOCC1>>[ClH:24].[NH2:7][C@@H:8]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:9]([N:11]1[CH2:12][CH:13]([OH:15])[CH2:14]1)=[O:10]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 69687358HCID 69687358, compound

Product 1

HCID 69687670HCID 69687670, compound

Conditions

Temperature
25 °C

Procedure

[(1S)-Benzyl-2-(3-hydroxy-azetidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (515 mg, 1.6 mmol) was dissolved in cold 4N HCl-dioxane, the mixture stirred 2 h at 25° C., concentrated, and the residue with ether giving a colorless solid (415 mg, 100%).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-360dee2c65324de1bbc7844bf421a0ca
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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