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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 651220Generated: October 30, 2026

Potassium Carbonate → N-(3-methoxyphenyl)-2-phenylquinazolin-4-amine

https://huagongshe.com/reaction/651220

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant4-Chloro-2-phenylquinazolineHCID 80977—
SolventIsopropanolHCID 3776—
ProductN-(3-methoxyphenyl)-2-phenylquinazolin-4-amineHCID 4841865—

Reaction Steps

4-Chloro-2-phenylquinazoline, 2 equivalents, 3-methoxyanilinyl, 2 equivalents, and potassium carbonate, 2 equivalents, were dissolved in 10 mL isopropanol and refluxed for 2 hours. The precipitated product formed was filtered and washed with water. Recrystallization from methanol provided the product as a white solid that was found to be homogenous by thin layer chromatography (TLC) and confirmed by EIMS.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06277989B1
Source datasetuspto-grants-2001_08
ORD IDord-dc33460735504293812160d126e6febd
Source noteuspto-grants-2001_08