Potassium Carbonate → N-(3-methoxyphenyl)-2-phenylquinazolin-4-amine

HRID 651220Notes

Reaction equation

HRID 651220 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1.[C:18](=[O:21])([O-])[O-].[K+].[K+]>C(O)(C)C>[C:12]1([C:4]2[N:3]=[C:2]([NH:5][C:6]3[CH:11]=[CH:10][CH:9]=[C:8]([O:21][CH3:18])[CH:7]=3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 809774-Chloro-2-phenylquinazoline

Product 1

HCID 4841865N-(3-methoxyphenyl)-2-phenylquinazolin-4-amine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-Chloro-2-phenylquinazoline, 2 equivalents, 3-methoxyanilinyl, 2 equivalents, and potassium carbonate, 2 equivalents, were dissolved in 10 mL isopropanol and refluxed for 2 hours. The precipitated product formed was filtered and washed with water. Recrystallization from methanol provided the product as a white solid that was found to be homogenous by thin layer chromatography (TLC) and confirmed by EIMS.

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe precipitated product formed
  3. filtrationwas filtered
  4. washwashed with water
  5. customRecrystallization from methanol

Sources & evidence

ORD record
ord-dc33460735504293812160d126e6febd
Source dataset
uspto-grants-2001_08
Patent number
US06277989B1

Reaction notes

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