Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 3-(N,N-dimethylamino)acrylate | HCID 121015 | — |
| Reactant | 3-Cyano-2,4,5-trifluoro-benzoyl chloride | HCID 18618761 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 53901687 | HCID 53901687 | — |
Reaction Steps
A solution of 55 g of 3-cyano-2,4,5-trifluoro-benzoyl chloride in 50 ml of toluene is added dropwise to a solution of 36,5 g of ethyl 3-dimethylamino-acrylate and 26,5 g of triethylamine in 140 ml of toluene at a temperature between 50 and 55° C. After stirring at 50° C. for 2 hours the reaction mixture is concentrated in vacuo. The crude product is used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06278013B1 |
|---|
| Source dataset | uspto-grants-2001_08 |
|---|
| ORD ID | ord-edff3e11a5aa4712a8648e3d6528fc30 |
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| Source note | uspto-grants-2001_08 |
|---|
