Triethylamine → HCID 53901687, compound

HRID 651288Notes

Reaction equation

[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](Cl)=[O:7])#[N:2].[CH3:15][N:16]([CH3:24])[CH:17]=[CH:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([C:18](=[CH:17][N:16]([CH3:24])[CH3:15])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:7])#[N:2]

Participants

Conditions

Temperature: 50 °C

Procedure

A solution of 55 g of 3-cyano-2,4,5-trifluoro-benzoyl chloride in 50 ml of toluene is added dropwise to a solution of 36,5 g of ethyl 3-dimethylamino-acrylate and 26,5 g of triethylamine in 140 ml of toluene at a temperature between 50 and 55° C. After stirring at 50° C. for 2 hours the reaction mixture is concentrated in vacuo. The crude product is used for the next step without further purification.

Workup

concentrationis concentrated in vacuo
customThe crude product is used for the next step without further purification

Sources & evidence

ORD record: ord-edff3e11a5aa4712a8648e3d6528fc30
Source dataset: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06278013B1

Reaction notes

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