反应详情

A stirred mixture of compound 2 (27.00 g, 0.118 mol) and hydrobromic acid (48% w/v, 350 ml) in glacial acetic acid (600 ml) was heated under reflux for 6 h. The cooled solution was poured into an ice/water mixture (11) and the resulting white precipitate was filtered off and washed with water until acid-free. Recrystallization, from glacial acetic acid afforded white crystals which were dried over potassium hydroxide in vacuo.

1. temperaturewas heated
2. temperatureunder reflux for 6 h
3. filtrationthe resulting white precipitate was filtered off
4. washwashed with water until acid-free
5. customRecrystallization
6. dry with materialfrom glacial acetic acid afforded white crystals which were dried over potassium hydroxide in vacuo