Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 651304Generated: October 25, 2026

Triphenylphosphine → (R)-(-)-2-(1Methylheptyloxy)benzonitrile

https://huagongshe.com/reaction/651304

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriphenylphosphineHCID 11776—
Reactant2-HydroxybenzonitrileHCID 11907—
Reactant(+)-2-OctanolHCID 2723888—
ReactantDiethyl azodicarboxylateHCID 5462977—
ReactantOctyl4'-methoxycarbonyloxy-4-biphenylcarboxylateHCID 18328376—
Product(R)-(-)-2-(1Methylheptyloxy)benzonitrileHCID 21308782—

Reaction Steps

Quantities: 2-(hydroxybenzonitrile (38) (9.17 g, 0.077 mol), (S)-(+)-octan-2-ol (10.00 g, 0.077 mol), DEAD (13.41 g, 0.077 mol), triphenylphosphine (20.20 g, 0.077 mol). The experimental procedure was as described for the preparation of compound 5. The crude product was purified by column chromatography (20% petrol/dichloromethane) to give a colourless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06278028B1
Source datasetuspto-grants-2001_08
ORD IDord-d3166a0e53b245d29c56fc1a0ebda336
Source noteuspto-grants-2001_08