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A mixture of 3-nitrobenzenethioamide (2.73 g, 15 mmol) and 3-methoxy-α-[bromoacetophenone (3.43 g, 15 mmol) in EtOH (30 mL) is heated under reflux for 18 h. It is cooled and filtered to give 4 g of 2-(3′-nitrophenyl)-4[(3′-methoxy)phenyl]thiazole as a yellow solid, mp. 122-123° C. 1H NMR (CDCl3): δ 3.94 (s, 3 H), 6.90-7.01 (dd, 1 H), 7.32-7.48 (t, 1 H), 7.50-7.75 (m, 4 H), 8.22-8.45 (dd,dd 2 H), 8.90 (dd, 1 H),

1. temperatureis heated
2. temperatureunder reflux for 18 h
3. temperatureIt is cooled
4. filtrationfiltered