Hydrochloric Acid → 2-Chlorobenzenesulfonic acid 3-[(4-amidinophenyl)methoxy]-5-methylphenyl ester hydrochloride

To a solution of 2-chlorobenzenesulfonic acid 3-[(4-cyanophenyl)methoxy]-5-methylphenyl ester (414 mg, 1.0 mmol), as prepared in the preceding step, in methylene chloride (10 mL) was added 37% HCl in ethanol (20 mL) at 0° C. The mixture was stirred at room temperature for 2 days. The solvent was evaporated and the residue was co-evaporated with methylene chloride several times. The residue was then dissolved in ethanol (20 mL) and ammonium carbonate (385 mg, 4.0 mmol) was added at 0° C. The mixture was stirred at room temperature overnight. The reaction mixture was partitioned between methylene chloride and 10% K2CO3 (50 mL). The organic phase was washed with 50 mL of 10% K2CO3 and dried over K2CO3. The solvent was removed in vacuo. The residue was diluted with CH2Cl2, treated with HCl in methanol (30 mL), and concentrated. The residue was then purified by crystallization (methanol and ethyl acetate) to give the title compound as a white solid(345 mg, 74%).

1. customThe solvent was evaporated
2. dissolutionThe residue was then dissolved in ethanol (20 mL)
3. stirringThe mixture was stirred at room temperature overnight
4. customThe reaction mixture was partitioned between methylene chloride and 10% K2CO3 (50 mL)
5. washThe organic phase was washed with 50 mL of 10% K2CO3
6. dry with materialdried over K2CO3
7. customThe solvent was removed in vacuo
8. additionThe residue was diluted with CH2Cl2
9. additiontreated with HCl in methanol (30 mL)
10. concentrationconcentrated
11. customThe residue was then purified by crystallization (methanol and ethyl acetate)

ORD record

ord-0d5d895eb8d44c3890d02d1094c87035

Source dataset

uspto-grants-2001_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06281206B1