3-(5,6,7,8-Tetrahydro-1-naphthalenyloxy)-pyrrolidine hydrochloride → (3S)-3-[(2,3--Dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine hydrochloride

HRID 651568Notes

Reaction equation

HRID 651568 reaction equation
[ClH:1].[C:2]1([O:12][CH:13]2[CH2:17][CH2:16][NH:15][CH2:14]2)[C:11]2[CH2:10][CH2:9][CH2:8]C[C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:18]1([O:28]C2CCN(CC3C=CC=CC=3)C2)C2CCCCC=2C=CC=1>>[ClH:1].[CH3:18][O:28][C:3]1[C:2]([O:12][C@H:13]2[CH2:17][CH2:16][NH:15][CH2:14]2)=[C:11]2[C:6](=[CH:5][CH:4]=1)[CH2:8][CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 144973773-(5,6,7,8-Tetrahydro-1-naphthalenyloxy)-pyrrolidine hydrochlorideHCID 224515093-[(5,6,7,8-Tetrahydro-1-naphthalenyl)oxy]-1-(phenylmethyl)-pyrrolidine

Product 1

HCID 9881884(3S)-3-[(2,3--Dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine hydrochloride

Procedure

3-[(5,6,7,8-Tetrahydro-1-naphthalenyl)oxy]-pyrrolidine hydrochloride m.p. 207° C., starting from 3-[(5,6,7,8-tetrahydro-1-naphthalenyl)oxy]-1-(phenylmethyl)-pyrrolidine

Sources & evidence

ORD record
ord-ca9e66eefe3149e8a83749b410337d64
Source dataset
uspto-grants-2001_08
Patent number
US06281243B1

Reaction notes

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