(S)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate → HCID 54264036, compound

HRID 651617Notes

Reaction equation

HRID 651617 reaction equation
[C:1]([O:5][C:6](=[O:14])[NH:7][C@H:8]1[CH2:12][CH2:11][NH:10][C:9]1=[O:13])([CH3:4])([CH3:3])[CH3:2].Br[CH2:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[C:22]([Cl:27])[CH:21]=[CH:20]2>>[C:1]([O:5][C:6](=[O:14])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([CH2:16][C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[N:23]=[C:22]([Cl:27])[CH:21]=[CH:20]3)[C:9]1=[O:13])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 10750535(S)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamateHCID 112768896-(Bromomethyl)-2-chloroquinoline

Product 1

HCID 54264036HCID 54264036, compound

Procedure

The title compound is prepared from (2-oxopyrrolidin-3-(S)-yl)-carbamic acid tert-butyl ester as described in EXAMPLE 1, Part H using 6-bromomethyl-2-chloro-quinoline in place of 7-bromomethyl-1-chloroisoquinoline. The crude product is purified by column chromatography eluting with a gradient of 2% MeOH/CH2Cl2 to 4% MeOH/CH2Cl2 to afford the title compound as a beige solid.

Workup

  1. customThe crude product is purified by column chromatography
  2. washeluting with a gradient of 2% MeOH/CH2Cl2 to 4% MeOH/CH2Cl2

Sources & evidence

ORD record
ord-c4ca9aff67c247489647aa8d3fe48b13
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Reaction notes

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