反应详情

温度

50 °C

To a solution of 2-amino-5-methylthiophene-3-carboxylic acid methyl ester (13.7 g, 80 mmol) in MeOH/H2O/THF (400 mL, 1:1:1) is added LiOH.H2O (16 g, 400 mmol). The solution is heated to 50° C. After 4 hours, the solution is concentrated. The resulting residue is dissolved in water. The pH of the solution is adjusted to between 5-6 using 1 N HCl. The precipitate is collected by filtration, washed with a small amount of water and is dried under vacuum. The title compound (12 g, 76 mmol) is obtained as a yellow solid.

1. concentrationthe solution is concentrated
2. dissolutionThe resulting residue is dissolved in water
3. filtrationThe precipitate is collected by filtration
4. washwashed with a small amount of water
5. customis dried under vacuum