HRID651691

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21708499

未命名化合物

HCID53799531

未命名化合物

结构：CC(C)(C)OC(=O)CN[C@H]1CCN(Cc2ccc3c(N)ncnc3c2)C1=O.O=C(O)C(F)(F)F

HCID70081978

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CN(CC=Cc1ccc(Cl)s1)[C@H]1CCN(C(N)c2ccc3cncnc3c2)C1=O.O=C(O)C(F)(F)F

HCID70121911

未命名化合物

PROCEDURE

实验过程

Same procedure as EXAMPLE 103, but using {[1-(4-aminoquinazolin-7-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amino}acetic acid tert-butyl ester trifluoroacetate instead of 3-(S)-amino-1-(4-aminoquinazolin-7-ylmethyl)pyrrolidin-2-one hydrochloride, and 3-(5-chlorothiophen-2-yl)allyl bromide instead of added 2-bromomethyl-1-tert-butoxycarbonyl-5-chloroindole.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8ee361fc867949d380effcec4478bac2
来源数据集: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06281227B1
来源说明: uspto-grants-2001_08

反应 SMILES

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]([O:12][C:13](=[O:34])[CH2:14][NH:15][C@H:16]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]2[CH:31]=[C:30]3[C:25]([C:26](N)=[N:27][CH:28]=[N:29]3)=[CH:24][CH:23]=2)[C:17]1=[O:33])(C)(C)C.[Cl:35][C:36]1[S:40][C:39]([CH:41]=[CH:42][CH2:43]Br)=[CH:38][CH:37]=1.BrCC1[N:48](C(OC(C)(C)C)=O)C2C(C=1)=CC(Cl)=CC=2>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][O:12][C:13](=[O:34])[CH2:14][N:15]([C@H:16]1[CH2:20][CH2:19][N:18]([CH:21]([NH2:48])[C:22]2[CH:31]=[C:30]3[C:25]([CH:26]=[N:27][CH:28]=[N:29]3)=[CH:24][CH:23]=2)[C:17]1=[O:33])[CH2:43][CH:42]=[CH:41][C:39]1[S:40][C:36]([Cl:35])=[CH:37][CH:38]=1