HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromomethyl-1-tert-butoxycarbonyl-5-chloroindole → {[1-(Aminoquinazolin-7-ylmethyl)-2-oxopyrrolidin-3-(S)-yl][3-(5-chlorothiophen-2-yl)allyl]amino}acetic acid methyl ester trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromomethyl-1-tert-butoxycarbonyl-5-chloroindole | HCID 21708499 | — |
| Reactant | 3-(5-Chlorothiophen-2-yl)allyl bromide | HCID 53799531 | — |
| Reactant | {[1-(4-aminoquinazolin-7-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amino}acetic acid tert-butyl ester trifluoroacetate | HCID 70081978 | — |
| Product | {[1-(Aminoquinazolin-7-ylmethyl)-2-oxopyrrolidin-3-(S)-yl][3-(5-chlorothiophen-2-yl)allyl]amino}acetic acid methyl ester trifluoroacetate | HCID 70121911 | — |
Reaction Steps
Same procedure as EXAMPLE 103, but using {[1-(4-aminoquinazolin-7-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amino}acetic acid tert-butyl ester trifluoroacetate instead of 3-(S)-amino-1-(4-aminoquinazolin-7-ylmethyl)pyrrolidin-2-one hydrochloride, and 3-(5-chlorothiophen-2-yl)allyl bromide instead of added 2-bromomethyl-1-tert-butoxycarbonyl-5-chloroindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06281227B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-8ee361fc867949d380effcec4478bac2 |
| Source note | uspto-grants-2001_08 |