反应详情

温度

0 °C

6-Imidazol-1-yl-1-methyl-1H-indole (7.0 g, 35.5 mmol) was dissolved in CH2Cl2 (100 mL) (dried under 3A molecular sieves) at 0° C. A solution of oxalyl chloride in CH2Cl2 (2 M, 35.5 mL, 71 mmol) was added dropwise over 10 min. The mixture was stirred at 0° C. for 1.5 h and evaporated. Ether (100 mL) was added to the solid residue and after the mixture was stirred for 30 min, the resulting yellow solid was filtered off, washed with ether and dried under vacuum for 30 min. 1-Methyl-3-indoleacetimidic acid isopropyl ester hydrochloride (9.6 g, 36 mmol) and CH2Cl2 (200 mL) were added to the yellow solid at 0° C. Et3N (dried over 3A° molecular sieves) (30 mL) was added dropwise over 10 min. The orange-red mixture was stirred at room temperature overnight. The mixture was diluted with CH2Cl2 (300 mL) and washed with aqueous Na2CO3 (2×200 mL). The aqueous layer was back extracted with CH2Cl2 (100 mL). The combined organic extracts were washed with brine, dried (K2CO3) and evaporated. MeOH (100 mL) and concentrated HCl (37%, 10 mL) were added and the mixture was heated at reflux for 2 h. The reaction mixture was cooled, diluted with water (200 mL) and EtOAc (200 mL). The mixture was made basic using solid K2CO3 and extracted with EtOAc (4×200 mL). The combined organic extracts were washed with aqueous Na2CO3 (2×200 mL) brine and dried (K2CO3). The mixture was passed through a pad of silica gel (10×10 cm) and the pad was washed with 10% methanol in EtOAc. Evaporation of the combined eluates gave the crude product as an orange solid. Recrystallization of the crude product using EtOAc, MeOH and CHCI3 gave 3-(6-imidazol-1-yl-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione (5.0 g, 33%) as an orange solid.

1. customevaporated
2. additionEther (100 mL) was added to the solid residue
3. stirringafter the mixture was stirred for 30 min
4. filtrationthe resulting yellow solid was filtered off
5. washwashed with ether
6. customdried under vacuum for 30 min
7. stirringThe orange-red mixture was stirred at room temperature overnight
8. washwashed with aqueous Na2CO3 (2×200 mL)
9. extractionThe aqueous layer was back extracted with CH2Cl2 (100 mL)
10. washThe combined organic extracts were washed with brine
11. dry with materialdried (K2CO3)
12. customevaporated
13. additionMeOH (100 mL) and concentrated HCl (37%, 10 mL) were added
14. temperaturethe mixture was heated
15. temperatureat reflux for 2 h
16. temperatureThe reaction mixture was cooled
17. additiondiluted with water (200 mL) and EtOAc (200 mL)
18. extractionextracted with EtOAc (4×200 mL)
19. washThe combined organic extracts were washed with aqueous Na2CO3 (2×200 mL) brine
20. dry with materialdried (K2CO3)
21. washthe pad was washed with 10% methanol in EtOAc
22. customEvaporation of the combined eluates
23. customgave the crude product as an orange solid
24. customRecrystallization of the crude product