Ammonium Hydroxide → HCID 21709096, compound

Participants

Reaction Steps

(6-Imidazol-1-yl-1-methyl-1H-indol-3-yl)acetic acid methyl ester (230 mg, 0.85 mmol) was suspended in concentrated NH4OH (5 mL) in a 100 mL flask and stirred in a sealed flask for 24 h. Lyophilization of the mixture gave a crude product, which was chliomatographed on silica gel using 2-8% MeOH in CH2Cl2 to give (6-imidazol-1-yl-1-methyl-1H-indol-3-yl)acetamide (145 mg, 67%).

Provenance & Evidence