Ammonium Hydroxide → HCID 21709096, compound

HRID 651756Notes

Reaction equation

HRID 651756 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[CH:11][CH:12]=2)[N:7]([CH3:19])[CH:6]=1.[NH4+:21].[OH-]>C(Cl)Cl>[N:14]1([C:10]2[CH:9]=[C:8]3[C:13]([C:5]([CH2:4][C:3]([NH2:21])=[O:2])=[CH:6][N:7]3[CH3:19])=[CH:12][CH:11]=2)[CH:18]=[CH:17][N:16]=[CH:15]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 70139078HCID 70139078, compound

Product 1

HCID 21709096HCID 21709096, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(6-Imidazol-1-yl-1-methyl-1H-indol-3-yl)acetic acid methyl ester (230 mg, 0.85 mmol) was suspended in concentrated NH4OH (5 mL) in a 100 mL flask and stirred in a sealed flask for 24 h. Lyophilization of the mixture gave a crude product, which was chliomatographed on silica gel using 2-8% MeOH in CH2Cl2 to give (6-imidazol-1-yl-1-methyl-1H-indol-3-yl)acetamide (145 mg, 67%).

Workup

  1. customLyophilization of the mixture gave a crude product, which

Sources & evidence

ORD record
ord-80adc5bf79a24928a54d5a3e619289c2
Source dataset
uspto-grants-2001_08
Patent number
US06281356B1

Reaction notes

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