HRID651790

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13638278

未命名化合物

结构：CC(C)C[C@@H](C(=O)NN)[C@H](CCCc1ccccc1)C(=O)OC(C)(C)C

HCID70200108

未命名化合物

结构：CC(C)C[C@@H](C(=O)NN1C(=O)NC2(CCC2)C1=O)[C@H](CCCc1ccccc1)C(=O)NOCc1ccccc1

HCID86757300

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@@H](C(=O)NN1C(=O)NC2(CCC2)C1=O)[C@H](CCCc1ccccc1)C(=O)NO

HCID86757299

未命名化合物

PROCEDURE

实验过程

The 2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenylbutyl]-4-methyl-N-(6,8-dioxo-5,7-diazaspiro[3.4]oct-7-yl)valeramide used as the starting material was prepared in a manner analogous to that described in Example 7, parts (ii) and (iii) starting from 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-4-methylvalerohydrazide and ethyl 1-isocyanato-1-cyclobutane carboxylate.

WORKUP

后处理

customwas prepared in a manner analogous to

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1c3ad0ad08dd46d5ad88203428e50d7b
来源数据集: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06281363B1
来源说明: uspto-grants-2001_08

反应 SMILES

C([O:8][NH:9][C:10]([C@H:12]([C@@H:22]([CH2:36][CH:37]([CH3:39])[CH3:38])[C:23]([NH:25][N:26]1[C:33](=[O:34])[C:29]2([CH2:32][CH2:31][CH2:30]2)[NH:28][C:27]1=[O:35])=[O:24])[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:11])C1C=CC=CC=1.C(OC([C@H]([C@@H](CC(C)C)C(NN)=O)CCCC1C=CC=CC=1)=O)(C)(C)C.N(C1(C(OCC)=O)CCC1)=C=O>>[OH:8][NH:9][C:10]([C@H:12]([C@@H:22]([CH2:36][CH:37]([CH3:39])[CH3:38])[C:23]([NH:25][N:26]1[C:33](=[O:34])[C:29]2([CH2:30][CH2:31][CH2:32]2)[NH:28][C:27]1=[O:35])=[O:24])[CH2:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:11]