HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-isocyanatocyclobutane-1-carboxylate → 2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenylbutyl]-4-methyl-N-(6,8-dioxo-5,7-diazaspiro[3,4]oct-7-yl)valeramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-isocyanatocyclobutane-1-carboxylate | HCID 13638278 | — |
| Reactant | 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-4-methylvalerohydrazide | HCID 70200108 | — |
| Reactant | 2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenylbutyl]-4-methyl-N-(6,8-dioxo-5,7-diazaspiro[3.4]oct-7-yl)valeramide | HCID 86757300 | — |
| Product | 2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenylbutyl]-4-methyl-N-(6,8-dioxo-5,7-diazaspiro[3,4]oct-7-yl)valeramide | HCID 86757299 | — |
Reaction Steps
The 2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenylbutyl]-4-methyl-N-(6,8-dioxo-5,7-diazaspiro[3.4]oct-7-yl)valeramide used as the starting material was prepared in a manner analogous to that described in Example 7, parts (ii) and (iii) starting from 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-4-methylvalerohydrazide and ethyl 1-isocyanato-1-cyclobutane carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06281363B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-1c3ad0ad08dd46d5ad88203428e50d7b |
| Source note | uspto-grants-2001_08 |