Benzyl chloroformate → HCID 21709313, compound

HRID 651793Notes

Reaction equation

HRID 651793 reaction equation
[C:1]([N:6]1[CH2:11][CH2:10][C:9]([C:17]([O:19][CH2:20][CH3:21])=[O:18])([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:8][CH2:7]1)([O:3][CH2:4][CH3:5])=[O:2].ClC(OC[C:27]1[CH:32]=[CH:31]C=[CH:29][CH:28]=1)=O>>[C:17]([C:9]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:10][CH2:11][N:6]([C:1]([O:3][CH2:4][C:5]2[CH:31]=[CH:32][CH:27]=[CH:28][CH:29]=2)=[O:2])[CH2:7][CH2:8]1)([O:19][CH2:20][CH3:21])=[O:18]

Participants

3

Reactant 2

HCID 10387Benzyl chloroformateHCID 126988091,4,4-Triethyl 1,4,4-piperidinetricarboxylate

Product 1

HCID 21709313HCID 21709313, compound

Procedure

In a manner analogous to that described by S. Huybrechts and G. J. Hoornaert, Synthetic Communications, 11 (1), 17-23 (1981) for the preparation of 1,4,4-tricarbethoxypiperidine but using benzyl chloroformate in place of ethyl chloroformate there was obtained benzyl 4,4-dicarbethoxypiperidine-1-carboxylate in the form of an oil.

Sources & evidence

ORD record
ord-6102e0ca8c644c8b83e8ee092e2c72c4
Source dataset
uspto-grants-2001_08
Patent number
US06281363B1

Reaction notes

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