HCID 70238645, compound → HCID 70202972, compound

HRID 651820Notes

Reaction equation

HRID 651820 reaction equation
[C:1]([NH:9][CH2:10][C@@H:11]([C@@H:19]([CH2:34][CH:35]([CH3:37])[CH3:36])[C:20]([NH:22][NH:23]C(OCC1C=CC=CC=1)=O)=[O:21])[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[C:1]([NH:9][CH2:10][C@@H:11]([C@@H:19]([CH2:34][CH:35]([CH3:37])[CH3:36])[C:20]([NH:22][NH2:23])=[O:21])[C:12]([O:14][C:15]([CH3:17])([CH3:18])[CH3:16])=[O:13])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 70238645HCID 70238645, compound

Product 1

HCID 70202972HCID 70202972, compoundYield 98.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 0.81 g of 2(R)-[2-benzamido-1(R)-(tert-butoxycarbonyl)ethyl]-2′-benzyloxycarbonyl-4-methylvalerohydrazide in 10 ml of ethanol was hydrogenated in the presence of 0.080 g of 10% palladium-on-carbon for 4 hours. The catalyst was removed by filtration and evaporation gave 0.59 g of 2(R)-[2-benzamido-1(R)-(tert-butoxycarbonyl)ethyl]-4-methylvalerohydrazide in the form of a white solid.

Workup

  1. customThe catalyst was removed by filtration and evaporation

Sources & evidence

ORD record
ord-f403201786e64f37ae4e8c3266a528bc
Source dataset
uspto-grants-2001_08
Patent number
US06281363B1

Reaction notes

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