3,3-Dimethylbutanal → Neotame

HRID 651840ノート

反応式

HRID 651840 の反応式
[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH:4]=O.[CH3:8][O:9][C:10]([C@@H:12]([NH:20][C:21]([C@@H:23]([NH2:28])[CH2:24][C:25]([OH:27])=[O:26])=[O:22])[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:11].[H][H]>>[CH3:1][C:2]([CH2:3][CH2:4][NH:28][C@H:23]([C:21]([NH:20][C@H:12]([C:10]([O:9][CH3:8])=[O:11])[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:22])[CH2:24][C:25]([OH:27])=[O:26])([CH3:7])[CH3:6]

参加物

4

反応物 3

HCID 763353,3-DimethylbutanalHCID 134601AspartameHCID 178418361HCID 178418361、化合物

生成物 1

HCID 9810996Neotame

実験手順

According to the second and third steps of the present invention, 3,3-dimethylbutyraldehyde is added to the mixture and reacted with aspartame in the presence of the catalyst and in the presence of hydrogen for a time and at a temperature sufficient to produce neotame. 3,3-Dimethylbutyraldehyde can be added slowly or all at once to the reaction mixture. When the aldehyde is gradually added, typically it is added over the course of about 2 to 8 hours, preferably from about 4 to 6 hours. It is important to note that the reactants, i.e., aspartame, catalyst, aldehyde, can be added in any order.

後処理

  1. additionis added to the mixture

出典と根拠

ORDレコード
ord-9f5a8505e053408099788c8a27c8fb79
出典データセット
uspto-grants-2001_08
特許番号
US06281380B1

反応ノート

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