Hydrogen Peroxide → HCID 13713873, compound

HRID 651917Notes

Reaction equation

HRID 651917 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:12]1[C:20](=[O:21])[C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[C:13]1=[O:22])[NH:8][C:7](=[O:23])[CH2:6][NH:5]2.[OH-].[Na+].O.OO>CCOCC>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:12]1[C:13](=[O:22])[C:14]3[CH2:15][CH2:16][CH2:17][CH2:18][C:19]=3[C:20]1=[O:21])[NH:8][C:7](=[O:23])[CH:6]=[N:5]2

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14798Sodium HydroxideHCID 178516728HCID 178516728, compound

Product 1

HCID 13713873HCID 13713873, compoundYield 74.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-(3,4-Dihydro-6-fluoro-2(1H)-quinoxalinon-7-yl)-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (0.43 g) was added to a mixture of sodium hydroxide (0.16 g), water (2.1 ml) and 30% aqueous hydrogen peroxide (0.21 ml), and the resultant mixture was stirred at room temperature for 16 hours. Ether was added thereto to separate an aqueous layer, which was adjusted to pH 4 with acetic acid. The precipitated crystals were collected by filtration and washed with water to give 2-(6-fluoro-2(1H)-quinoxalinon-7-yl)-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (0.32 g). m.p., >300° C.

Workup

  1. customto separate an aqueous layer, which
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-b0ad0e020d0b449d972d002cc63c2767
Source dataset
uspto-grants-1987_06
Patent number
US04670042

Reaction notes

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